The Senior Officers provide leadership for the activities of the University of Melbourne. The Vice-Chancellor is Chief Executive Officer and Principal.
- Vice-Chancellor - Professor Glyn Davis
- Provost - Professor Margaret Sheil
- Deputy Vice-Chancellor (Research) - Professor Jim McCluskey
- Deputy Vice-Chancellor (Engagement) - Professor Sue Elliott
- Deputy Vice-Chancellor (Academic) - Professor Pip Pattison
- President, Academic Board - Professor Ruth Fincher
- Senior Vice Principal - Mr Ian Marshman